In humans, although the parasite undergoes development in the liver, it is the erythrocytic cycle that is responsible for disease.
P falciparum is transmitted by female Anopheles mosquitoes. Severe malaria is a multisystem disease, and the outcome often depends on the degree of vital organ dysfunction. Metabolic acidosis, mainly a lactic acidosis, is common at all ages. In older children seizures and cerebral malaria predominate whereas in adults acute renal failure, acute pulmonary oedema, liver dysfunction, and cerebral malaria may all occur. 1 In the first 2 years of life severe anaemia is a common presenting feature of severe malaria. The manifestations of severe malaria differ depending on the age of the patient and previous exposure.
Severe malaria occurs predominantly in patients with little or no background immunity-that is, children growing up in endemic areas, or travellers or migrants who come from areas without malaria, but are exposed to malaria later in life. There are four species of human malaria, but Plasmodium falciparumcauses nearly all the deaths and neurological complications. Malaria affects about 5% of the world's population at any time and causes somewhere between 0.5 and 2.5 million deaths each year. Malaria is the most important of the parasitic diseases of humans, and its neurological complication, cerebral malaria is arguably one of the most common non-traumatic encephalopathies in the world. Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments. With appropriate antimalarial drugs, the prognosis of cerebral malaria often depends on the management of other complications-for example, renal failure and acidosis. Artemisinin derivatives have made an impact on treatment, but other drugs may be required. Antimalarial drugs, however, remain the only intervention that unequivocally affects outcome, although increasing resistance to the established antimalarial drugs is of grave concern. Recent studies have elucidated the molecular mechanisms of pathogenesis and raised possible interventions. The clinical presentation and pathophysiology differs between adults and children.
The pathogenesis is heterogenous and the neurological complications are often part of a multisystem dysfunction. So on that note, I'm recommending The Black Sleep.Cerebral malaria may be the most common non-traumatic encephalopathy in the world. I thought this was a very effective chiller that was underrated considering the cast.
Other cast members worth noting: Phyllis Stanley as Rathbone's nurse, Sally Yarnell as another of the underground "patients", Claire Carleton as a "customer" of Tamiroff's, and John Sheffield as a Scotland Yard detective investigating the whole thing. There's also an amusing performance by Akim Tamiroff as another associate of Rathbone's. Herbert Rudley is his reluctant assistant and Patricia Blair (or Blake as she's credited here) is the daughter of Chaney who plays another mute who was once a functioning human being. The star is Basil Rathbone as a mad doctor who performs brain surgeries because of a secret I don't want to reveal here.
#Tumor en el cerebro tiene cura series#
He is joined here by fellow horror stalwarts John Carradine (gloriously hammy here), Lon Chaney, Jr., and fellow Ed Wood-directed series castmate Tor Johnson. He plays a mute butler who doesn't really do much but still has somewhat of a presence and is nothing to be ashamed about.
#Tumor en el cerebro tiene cura movie#
While Plan 9 from Outer Space is often considered to be Bela Lugosi's last film, considering that movie consisted of test scenes meant for a different movie, the actual final picture of which Lugosi actively participated in should actually be this one.
0 kommentar(er)
